ANALYSIS OF POTASSIUM LOSARTAN FROM COMPOUNDING PHARMACIES OF MONTES CLAROS, MG, BRAZIL

Abstract

Potassium losartan is an example of AT1 receptors antagonist, and it is used for hypertension treatment. Potassium losartanoften is prepared at compounding pharmacies. Thus, the aim of this work is to analyze the dosage forms of potassium Losartan prepared by compounding pharmacies at Montes Claros, MG. Capsules containing 50 mg losartan were purchased commercially in three randomly chosen compounding pharmacies. The average weight of the capsules ranged from 0.136 g to 0.147 g for the same prescription of 50 mg. The test for disintegration of the capsule as described in the methodology above, lies within the parameters established in the Brazilian Pharmacopoeia. It is not conclusive analysis of the mean weight of the capsules, while the disintegration test demonstrated a good quality capsules analyzed.