DOSE ADJUSTMENT OF MEDICINES ACCORDING TO RENAL FUNCTION IN A UNIVERSITY HOSPITAL

Abstract

This study evaluated the need for dose adjustment of medications according to the renal function of patients in the medical clinic in a university hospital in the State of Pernambuco, Brazil. The study follows a cross-sectional design. The prescriptions of patients hospitalized from September 2019 to February 2020 were analyzed. The study follows a retrospective longitudinal design. The prescriptions of patients hospitalized from September 2019 to February 2020 were analyzed. During this period, 245 patients had 
their prescriptions evaluated. Of these, 45 patients (18.3%) were excluded due to the absence of creatinine information and 152 (62.0%) because they did not require adjustment of the dose of medication because renal function was within normal parameters. The remaining 48 patients were included in the final study, because they presented altered renal function and used renal excreted drugs. It was found that 60.4% received at least one prescription during hospitalization with an unadjusted dose of medication according to
renal function. Among the drugs with unadjusted doses, antimicrobials were the most frequent. This study warns of the importance of monitoring renal function, especially when prescription drugs excreted renally.