GENETIC CHANGES AND THEIR IMPLICATIONS FOR RESISTANCE TO ANESTHESIA AND THE CHOICE OF ANESTHETIC TECHNIQUE: ANALYSIS OF CLINICAL ASPECTS

Abstract

Choosing the type of anesthetic to be used in patients with genetic variations requires a detailed study of genetic changes and constant patient  onitoring. Thus, it was aimed to analyze the implications that genetic changes  represent in resistance to anesthetics and the choice of anesthetic techniques. A narrative review was conducted in May 2019 in the LILACS  (Latin American and Caribbean Literature in Health Sciences), Medline,  Scopus, Cochrane Library, and Web of Science databases. Twelve articles  were selected with the following descriptors: genetics, local anesthesia;  monitoring; sodium channels; neuromuscular monitoring. The literature on  the genetics of resistance to anesthesia deals with genetic and clinical  aspects of related diseases, demonstrating the evolution of knowledge of  genetics and anesthesia, in addition to highlighting the techniques used in  these cases. The evidence found described genetic and clinical information  about the diseases, emphasizing the implications of late, early or unexpected effects related to anesthetic induction.