ANTIMICROBIAL AND ANTIVIRAL AGENTS WITH POTENTIAL THERAPEUTIC USE FOR COVID-19

Abstract

The disease caused by the new SARS-CoV-2 coronavirus, called COVID-19, has already infected more than 6.5 million people worldwide. To date, there is no proven eff ective treatment against the virus, but some drugs already used in other diseases have shown eff ectiveness in vitro or even in humans, such as some antimicrobial agents. The objective of this bibliographic research was to provide an overview of the published evidence, up to the research date, about experimental studies and clinical trials that used antimicrobial drugs as a treatment proposal for the disease by the new coronavirus. 75 articles from journals indexed in the MEDLINE database were included. The results showed that the drugs Lopinavir/Ritonavir, chloroquine and hydroxychloroquine demonstrated to act in the clinical improvement of patients diagnosed with COVID-19. However, more evidence is needed to confi rm the data currently available.